Health knowledge, and habits are known to begin during early childhood by vicarious learning from parents, siblings, caregivers, and peers. Thus, approaches that aim to modify behaviors of young Mexican children, need to understand children and caregivers’ knowledge, attitudes, and perceptions, as well as the factors that influence them. Considering this, the goal of the HOPS study is to document knowledge, attitudes, and perceptions about stress, obesity, diabetes, and yoga across three groups of preschool age children and their mothers. This qualitative study aims to document the attitudes and perceptions towards factors associated with early obesity development from three different groups: Mexicans in Mexico, first generation Mexican immigrants, and second generation Mexican descent. Data from this study will inform early childhood obesity prevention efforts interested in addressing the physical and mental health of families of Mexican descent in Mexico and the U.S.